Description
Autoantibodies recognising endocrine organs are found alone or with related autoantibodies in a group of complex disorders termed Autoimmune polyendocrinopathy syndromes (APS). The autoantibodies against specific organs correlate with disease affecting those organs. Antibodies include anti-adrenal, thyroid, parathyroid, pancreas (diabetes), gastric parietal cell, ovary or testes (see specific pages). These autoantibodies are found individually or together in autoimmune disorders forming part of two types of polyglandular autoimmune syndromes (PAS). Type I is a triad of Addison’s disease, hypoparathyoidism and chronic mucocutaneous candidiasis: Type II is associated with primary hypothyroidism and/or type 1 diabetes. Autoimmune gastritis can also be associated.For further details see individual tests.
Indication
Autoimmune polyendocrinopathy syndromes (APS, PAS or PGA).
Interpretation
See individual tests.
Sample
Serum Separator Tube (SST)
Assay details
Indirect immunofluorescence using primate tissues
Restrictions
Referred tests
Reference range
Negative/positive
Assay range notes
See individual tests
Turnaround time
28 days
Analysing laboratory
Sheffield PRU