Cryoglobulins are proteins (immunoglobulins) which precipitate out of serum at temperatures lower that normal body temperature. Although some cryoglobulins precipitate at temperatures as high as 30-35°C. in the laboratory, samples are cooled to 4°C to test for cryoglobulins. Cryoglobulinaemia is primarily a laboratory diagnosis identifying abnormal immunoglobulins or immune complexes which might precipitate in specific … Continue reading Cryoglobulin Determination