Clinical Use:
Background: Myoglobin is an intracellular, oxygen-binding, haem protein found in cardiac and skeletal muscle. Myoglobin is noted for its rapid release into the circulation following tissue injury. Elevated levels may be found in cases of muscle damage, such as acute and chronic skeletal muscle disease, renal failure, myocarditis, open-heart surgery and after heavy exercise.Following myocardial infarction myoglobin is released into the circulation as early as 2-4 hours after cell damage, peaks at 9-12 hours and returns to normal after 24-36 hours.

In the absence of skeletal muscle trauma, myoglobin has been used as an early indicator of MI and so is useful as a rule out indicator. Myoglobin has a negative predictive value of 99%.

Reference Ranges: Myoglobin median value in an apparently healthy population as determined by Siemens = 36.4 ug/LResults: Greater than 110 ug/L are suggestive of myocardial infarcation
Associated Diseases:
Patient Preparation:
Specimen Requirements: Sample type:

  • Serum

Sample identification:

  • Three patient identifiers from
    • Name
    • D.O.B.
    • Address
    • N.H.S. number
    • Unit Number

    should match on the specimen and request form. This check may be performed prior to centrifugation by the Central Sort department.

Turnaround Time: 24 hours
Additional Information:
Referred Test: