Clinical use: Steroid profiling is ideal for detection of altered steroid metabolism, whether due to defects in steroidogenic enzymes, associated with certain clinical states (e.g anorexia, porphyrias) or as a result of drug treatment.
Background: Urinary steroid profiling by GC and GC-MS provides qualitative and quantitative data on excretion of steroid metabolites. Most of these originate in the adrenal cortex, while the gonads after puberty contribute to the metabolites of androgens and 17a – Hydroxyprogesterone.A profile provides a composite picture of the quantitatively major biosynthetic and catabolic pathways. This is not synonymous with biological importance: metabolites of cortisol, progesterone, corticosterone and testosterone are readily detected whereas those of oestradiol and aldosterone are not, unless analysed by GC-MS in selected ion monitoring mode.
Reference ranges:
Associated diseases:
Patient preparation: None required
Specimen requirements: Urine – 20 mL urine in a plain universal container.
Turnaround time: 3 weeks
Additional information: Available on a named consultant basis only. Add consultant name to clinical details to allow this request to be processed.
www.labtestsonline.org.uk
Referred test: Referred test
Location: Kings Hospital, London
Page last updated on: 14 May 2015