The Thrombin Time (TT) assay is based on the ability of thrombin to catalyse the polymerisation of fibrinogen into a fibrin clot. The test is often used when routine screening results (mainly the APTT) are extended.
A normal thrombin time excludes abnormalities in the fibrin formation process of the coagulation cascade. A shortened thrombin time is rare and is observed in patients treated with certain forms of hereditary dysfibrinogenemia. A prolonged thrombin time indicates a fibrinogen abnormality, impairment of fibrin formation, and/or a thrombin inhibitory effect.
|Reference Range:||Current laboratory (adult, M/F) normal ranges are as follows:
14.5 – 18.5 seconds
|Min. Volume:||The volume of blood in coagulation samples must lie within the volume range as indicated by the size of the black fill arrow present on tubes. Volumes above or below the arrow will result in sample rejection to ensure validity of results.|
|Turnaround Time:||Urgent: 1 hour
Routine: 4 hours
|Age of Sample:||Samples will be rejected if received more than 8 hours after venepuncture.|
|Analysing Laboratory:||Coagulation (JCUH and FHN)|