Clinical Use:
Background: Vancomycin is a glycopeptide antibiotic that acts by inhibiting protein synthesis in bacteria. It is used to treat gram positive bacteria, such as staphylococcus aureus, and some facultative anaerobic gram negative bacteria. The therapeutic range for vancomycin is 30 to 40 mg/L at the peak concentration and 5 to 10 mg/L at the trough level. Toxicity may occur when serum vancomycin levels exceed 80 mg/L. At levels above 80 mg/L, vancomycin is potentially nephrotoxic and ototoxic. The normal half-life of vancomycin is approximately 6 hours, but clearance of the drug is dependent on renal function. It is important to monitor the level of serum vancomycin and adjust the dosage on an individual basis in patients with impaired renal function. Because of its ototoxicity, it is also important to monitor the vancomycin levels in patients receiving other ototoxic antibiotics.
Reference Ranges:
Associated Diseases:
Patient Preparation:
Specimen Requirements: Sample type:

  • Serum or Heparinized Plasma

Sample identification:

  • Three patient identifiers from
    • Name
    • D.O.B.
    • Address
    • N.H.S. number
    • Unit Number

    should match on the specimen and request form. This check may be performed prior to centrifugation by the Central Sort department.

Turnaround Time: 2 hours
Additional Information:
Referred Test: