Effects of morphine on the response to simulated haemorrhage and injury.
Attendance at four sessions at The James Cook University Hospital
- One pre-trial check-up (approximately one to two hours)
- One familiarisation session (approximately three hours)
- Two trial days (approximately three hours on each day)
Blood loss is simulated by lying with the hips and legs in a box and applying suction to the box to trap blood in the veins of the lower body: blood does not leave the body.
This technique is used to demonstrate haemorrhage in the Phase 1 Medicine course at Durham University and has been widely used by various research groups world-wide.
Subjects will also receive tourniquets around the legs.All subjects will receive a clinical dose of morphine on one trial day and saline (placebo) on another.
You will be asked to refrain from taking any medicines or drugs (including alcohol) on the day before the trial and from driving for 24 hours after each trial day. (Taxis will be arranged for transport to and from The James Cook University Hospital on trial days.)