Rifampicin

What is Rifampicin?

Rifampicin is an antibiotic used to treat certain bacterial infections, including tuberculosis. It does not work against viruses such as colds or flu.

How to take Rifampicin

Take on an empty stomach – 30 minutes before food or 2 hours after.
Take exactly as prescribed and try not to miss doses.

Before taking Rifampicin

Tell your doctor about any medical conditions which you have.
Tell your doctor about all medicines you take (including herbal or over-the-counter products).
Rifampicin can reduce the effectiveness of the contraceptive pill, ask about suitable alternatives.
Pregnancy: consult your doctor.
Breastfeeding: generally safe; may colour breast milk orange red (harmless).

While taking Rifampicin

Your urine, sweat, tears and saliva may turn orange red, this is harmless.
Soft contact lenses may become permanently stained.
If treatment lasts longer than 2 weeks, your doctor may check your liver and blood tests.

Common side effects

Nausea, vomiting (usually mild and improves over a few days).
Headache, dizziness, tiredness.
Muscle or joint aches.

Serious side effects seek urgent help

Allergic reaction: rash, itching, blisters, swelling of face/lips/eyes, difficulty breathing.
Signs of liver problems: yellow skin/eyes, dark urine, pale stools, severe nausea/vomiting.
Unusual bleeding, bruising or extreme tiredness.

Warning serious side effects

If you experience any of these symptoms, seek immediate medical attention.

Additional important information

Do not drink alcohol while on Rifampicin (increases risk of liver problems).
If you miss a dose: take it when you remember unless your next dose is due within six hours. Do not double-dose.
Continue treatment for as long as your doctor prescribes.

Storing Rifampicin

Keep out of reach of children.
Store below 25°C in a dry place, protected from light.

If you have questions, contact your doctor or pharmacist.

A manufacturer’s information leaflet is available in every rifampicin box. You can ask your nurse for a copy or view it online.

Patient Experience Team

South Tees Hospitals NHS Foundation Trust would like your feedback. If you would like to share your experience about your care and treatment or on behalf of a patient, please contact The Patient Experience Team who will help you to do this.

This service is based at James Cook University Hospital but also the Friarage Hospital in Northallerton, our community hospitals and community health services.

South Tees Hospitals NHS Foundation Trust