Clinical Use:
Background: Elastase 1 is a protease synthesised by pancreatic acinar cells and secreted into the duodenum. It is not degraded during transit and is concentrated in the faeces. Measurement of stool Elastase 1 allows the diagnosis or exclusion of pancreatic exocrine insufficiency, which can be caused by chronic pancreatitis, cystic fibrosis, pancreatic tumour, cholelithiasis or diabetes mellitus.
Reference Ranges:
  • Normal exocrine pancreatic sufficiency: 200 to >500 ug E1/g stool
  • Moderate to mild exocrine pancreatic insufficiency: 100 – 200 ug E1/g stool
  • Severe exocrine pancreatic insufficiency:
Associated Diseases:
Patient Preparation:
Specimen Requirements: Sample type:

  • A single spot stool sample in a plain, universal container.

Sample identification:

  • Three patient identifiers from
    • Name
    • D.O.B.
    • Address
    • N.H.S. number
    • Unit Number

    should match on the specimen and request form. This check may be performed prior to centrifugation by the Central Sort department. The appearance of the sample must be noted on the form prior to freezing, e.g loose, watery etc.

Turnaround Time: 4 weeks
Additional Information:
Referred Test: