Clicking on a link to an investigation will open the relevant test page
| Disease | Investigations appropriate for initial diagnostic investigations |
|---|---|
| Addison’s disease | Anti -adrenal, Ovary or Testes antibodies |
| α1 antitrypsin deficiency | α1 antitrypsin |
| Family screening for α1 antitrypsin deficiency (ONLY once a deficient sibling or spouse has been identified) | α1 antitrypsin α1 antitrypsin Phenotype |
| Allergy | IgE (total IgE) Allergen specific IgE (RAST) testing |
| (Extrinsic) allergic alveolitis (bird fanciers lung) | Avian precipitins |
| Anaphylactic reaction (especially adverse drug reactions) | Mast cell tryptase C3/C4 |
| Angioedema (hereditary or acquired) | C1 inhibitor C3/C4 Allergy testing if appropriate |
| Anti -phospholipid syndrome (APS) | Anti -cardiolipin antibodies Lupus anticoagulant (Haematology) Autoantibody screen C3/C4 |
| Bullous skin disorders | Anti -epidermal antibodies |
| C1 Inhibitor deficiency | C1 Inhibitor C3/C4 |
| Cerebellar ataxia | Anti -glutamic acid decarboxylase antibodies (GAD) |
| Chronic active hepatitis (CAH) | Autoantibody screen Immunoglobulins, Serum protein electrophoresis |
| Chronic lymphocytic leukaemia (CLL) | Immunoglobulins, Serum protein electrophoresis |
| Chronic obstructive airways disease (COPD) | α1 antitrypsin Immunoglobulins |
| Coeliac disease | Anti -tissue transglutaminase |
| Congenital heart block | Autoantibody screenENA Screen (Anti-Ro) |
| Connective tissue disease | Autoantibody screen (Includes C3/C4, rheumatoid factor and serum electrophoresis) |
| CREST syndrome | Autoantibody screen |
| Cryoglobulinaemia | Cryoglobulin screen(Includes C3/C4 and rheumatoid factor) |
| Deep venous thrombosis | Anti -cardiolipin Autoantibody screen C3/C4 |
| Dermatitis hepetiformis | Anti -tissue transglutaminase |
| Dermatomyositis | Autoantibody screen Anti-Jo1 |
| Diabetes (type 1) | Anti -pancreatic islet cell Ab Anti -GAD Antibodies |
| DLE | Autoantibody Screen |
| Dressler’s syndrome | Anti -cardiac muscle Ab |
| Emphysema | α1 antitrypsin Immunoglobulins |
| Fibrosing alveolitis | Autoantibody screen |
| Food allergy | Total IgE Food allergen screen |
| Glomerulonephritis | Autoantibody screen Anti -neutrophil cytoplasmic Ab (ANCA) Anti -glomerular basement membrane Ab (GBM) C3/C4 Immunoglobulins, Serum protein electrophoresis ASO titre -if strep. suspected |
| Goodpasture’s syndrome | Anti -glomerular basement membrane Ab (GBM) Anti -neutrophil cytoplasmic Ab (ANCA) |
| Graves disease | Anti -thyroid microsomal Ab |
| Guillain-Barré syndrome | Anti -GM1 and GQ1b antibodies |
| Haemolytic anaemia | Haptoglobin levels |
| Hashimotos Thyroditis | Anti -thyroid peroxidase (TPO) |
| Hereditary angioedema (HAE) | C1 Inhibitor C3/C4 |
| Juvenile chronic arthritis | Autoantibody screen Immunoglobulin, Serum protein electrophoresisC3/C4 |
| Lymphoproliferative disorders | Immunoglobulin, Serum protein electrophoresis |
| Malignant Paraprotein, myeloma screen | Immunoglobulin, Serum protein electrophoresis Urine electrophoresis (Bence-Jones) |
| Mastocytosis | Mast cell tryptase |
| Membranoproliferative glomerulonephritis (MPGN) | Anti -neutrophil cytoplasmic Ab (ANCA) C3/C4 |
| Microscopic polyangitis | Anti -neutrophil cytoplasmic Ab (ANCA) |
| Mixed connective tissue disease (MCTD) | Autoantibody screen C3/C4Anti -cardiolipin antibodies |
| Monoclonal gammopathy of uncertain significance (MGUS) | Immunoglobulin, Serum protein electrophoresis Urine electrophoresis (Bence-Jones) |
| Multiple sclerosis | Oligoclonal Bands: serum and CSF |
| Myasthenia gravis | Anti -acetylcholine receptor antibodies |
| Myeloma | Immunoglobulin, Serum protein electrophoresis Urine electrophoresis (Bence-Jones) |
| Neonatal liver disease | α1 antitrypsin |
| Non-Hodgkins lymphoma | Immunoglobulin, Serum protein electrophoresis Urine electrophoresis (Bence-Jones) |
| Paraneoplastic neurological syndromes | Anti -neuronal antibodies |
| Partial lipodystrophy | C3/C4 (screen for nephritic factor) |
| Pemphigoid | Epidermal antibodies |
| Pemphigus | Epidermal antibodies |
| Pernicious anaemia | Autoantibody screen |
| Polymyositis | Autoantibody Screen Anti -Jo1 |
| Premature ovarian failure | Anti -adrenal and ovary antibodies |
| Primary biliary cirrhosis | Autoantibody screen |
| Progressive system sclerosis | Autoantibody screen Anti -Scl70 |
| Raynaud’s | Autoantibody screen C3/C4 |
| Rheumatoid arthritis | Autoantibody screen C3/C4 |
| Rhinitis | Total IgE Inhaled (aero-)allergen screen |
| Sjogrens Syndrome | Autoantibody screen |
| Systematic sclerosis, scleroderma | Autoantibody screen C3/C4 |
| Systematic lupus erythematosis (SLE) | Autoantibody screen C3/C4 |
| Vasculitis | Autoantibody screen Anti -neutrophil cytoplasmic Ab (ANCA) C3/C4 |
| Waldendstrom’s macroglobulinaemia | Immunoglobulin, Serum protein electrophoresis Urine electrophoresis (Bence-Jones) |
| Wegener’s granulomatosis | Anti -neutrophil cytoplasmic Ab (ANCA) Autoantibody screen |
| Wilson’s disease | Caeruloplasmin levels |