Description
The autoantibody screen is used to detect autoantibodies characteristic of a wide range of autoimmune diseases, Autoantibodies recognising antigens in liver, kidney or stomach are detected. A test for rheumatoid factor is also carried out. The autoantibody screen detects anti-nuclear antibodies; gastric parietal cell antibodies, mitochondrial antibodies, liver-kidney microsomal and smooth muscle antibodies. A number of other autoantibodies of varying diagnostic value are also detected e.g anti-reticulin. Refer to pages defining individual autoantibodies for more information.
Indication
Initial investigation of autoimmune liver, stomach or connective tissue diseases.
Interpretation
See individual tests
Sample
Serum Separator Tube (SST)
Assay details
Indirect immunfluorescence mouse tissue (liver kidney stomach)
Reference range
Negative/positive
Assay range notes
Positive samples Titre 1:80 – >1:640
Turnaround time
3 – 5 days
Analysing laboratory
Immunology The James Cook University Hospital