Dehydroepiandrosterone Sulphate

Clinical Use: To investigate delayed or precocious puberty. diagnosis of a virilising adrenal tumour and monitoring recurrence after surgical removal. Differential diagnosis of Cushing’s syndrome due to an adrenal adenoma.
Background: The assay has little value in the investigation of acne, idiopathic hirsutism or infertility. Virilising adrenal tumours – These are often associated with an increased production of dehydroepiandrosterone sulphate which can be detected by analysis of serum or urine. Measurement is indicated in women if hirsutism and/or virilisation is of sudden onset and in prepubertal children when pubic/axillary hair appears prematurely or there are other features of masculinisation.

Cushing’s syndrome – Serum values below the normal reference range have been described in patients with cortisol excess due to adrenal adenoma.

Reference Ranges: 2.7 – 9.2 µmol/L
Associated Diseases:
Patient Preparation: None required
Specimen Requirements: A serum sample (SST) is required for analysis
Turnaround Time: 1 week
Additional Information:
Referred Test: Referred test