Clinical Use: Clonazepam testing is used to monitor the therapy and dosages being given to patients, it is also used to determine compliance of patients to the treatment. Clinicians check clonazepam level to assess toxicity.
Background: Clonazepam is a long-acting benzodiazepine restricted in use to those patients who have responded for seizure control only to diazepam, but who no longer respond to diazepam within non-toxic levels. It is an effective anticonvulsant, but used only as a last resort due to its side effects.

Clonazepam is benzodiazepine derivative that is useful alone or as an adjunct in the treatment of the Lennix-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. Clonazepam has been shown to be effective in patients with absence seizures (petit mal) who have failed to respond to succinimide therapy. In some studies, up to 30% of patients have shown a loss of anticonvulsant activity, often within three months of administration. In some cases, dosage adjustment may re-establish efficiency.

Reference Ranges: 80 – 270 nmol/L
Associated Diseases:
Patient Preparation: None required
Specimen Requirements: Serum – Plain (red top) Tube
Turnaround Time: 4 weeks
Additional Information:
Referred Test: Referred test
Location: National Society for Epilepsy