Sera from patients with idiopathic hypoparathyroidism (IHP) may contain antibodies to antigens of parathyroid cells. Such antibodies have been detected by indirect IF on sections of monkey parathyroid. They are not directed against parathyroid hormone, but against cytoplasmic antigens of parathyroid cells. Many of these patients have autoimmune polyendocrinopathies with antibodies to adrenal cortex and ovary membranes.
Investigation of Autoimmune hypoparathyroidism.
Antibodies to parathyroid cells have been found in the serum of approximately 38% of patients with IHP, 26% of patients with idiopathic Addison’s disease, 12% of patients with chronic thyroiditis, and 6% of controls. Since approximately 60% of patients with IHP do not have demonstrable parathyroid antibodies, a negative test obviously does not exclude IHP. On the other hand, a positive test, while indicating IHP, is not necessarily diagnostic, in that the patient might have adrenal insufficiency or thyroiditis, or a combination of these disorders.
Serum Separator Tube (SST)
Indirect immunfluorescence monkey issue.
Assay range notes
Positive results are expressed from +/- equivocal result to +++ very strong fluorescence, very high level of antibody.