|Background:||Gentamicin is an aminoglycoside antibiotic that is used primarily to treat serious infectious diseases caused by gram-negative bacilli. Gentamicin inhibits the normal process of protein synthesis in certain organisms. Gentamicin may be used in combination with other antibiotics to treat serious infections such as central nervous system infections (meningitis), urinary tract, respiratory tract, or gastrointestinal tract infections, and neonatal sepsis.
Most Streptococcus and some anaerobic organisms are resistant to gentamicin. Gentamicin has a narrow therapeutic range in serum of 5 to 10 mg/l (10.5 to 20.9 µmol/l) for peak levels and 1 to 2 mg/l (2.1 to 4.2 µmol/l) for trough levels.
Monitoring a patient’s serum gentamicin level is important in preventing drug-related side effects, which may occur when peak serum gentamicin levels exceed 10 to 12 mg/l (20.9 to 25.1 µmol/l) or when trough gentamicin levels exceed 2 mg/l (4.2 µmol/l). Because gentamicin shows an affinity for renal tissue and penetrates otoperilymph, excess gentamicin levels can cause renal toxicity and ototoxicity.
The elimination half-life of gentamicin is relatively short, approximately 2 to 3 hours. Therapeutic drug monitoring helps to ensure therapeutic levels and to minimize toxic accumulation of gentamicin.
Patients who are most susceptible to the toxic effects of gentamicin usually have impaired renal function, receive high doses, are critically ill neonates or undergo prolonged gentamicin therapy.
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|Turnaround Time:||2 hours|