Haptoglobin is a serum glycoprotein which binds free haemoglobin released on damage of red cells. The haptoglobin-Hb complex is cleared by the reticuloendothelial system. Consequently haptoglobin is depleted from serum in states of intravascular haemolysis. Haptoglobin levels rise as part of the acute phase response.
Detection and assessment of haemolytic conditions.
In haemolytic states, haptoglobin levels are usually extremely low or undetectable.
Serum Separator Tube (SST)
Increased levels of lipids (lipaemia), haemoglobin (haemiolysis), or the prescence of icterus in the assay sample may affect the assay result.
Male: 0.5 – 2.0g/L
Female: 0.4 – 1.6g/L
Assay range notes
Lower values are seen in children
5 – 7 days
Immunology The James Cook University Hospital