Description
Haptoglobin is a serum glycoprotein which binds free haemoglobin released on damage of red cells. The haptoglobin-Hb complex is cleared by the reticuloendothelial system. Consequently haptoglobin is depleted from serum in states of intravascular haemolysis. Haptoglobin levels rise as part of the acute phase response.
Indication
Detection and assessment of haemolytic conditions.
Interpretation
In haemolytic states, haptoglobin levels are usually extremely low or undetectable.
Sample
Serum Separator Tube (SST)
Assay details
Nephelometry
Restrictions
Increased levels of lipids (lipaemia), haemoglobin (haemiolysis), or the prescence of icterus in the assay sample may affect the assay result.
Reference range
Male: 0.5 – 2.0g/L
Female: 0.4 – 1.6g/L
Assay range notes
Lower values are seen in children
Turnaround time
5 – 7 days
Analysing laboratory
Immunology The James Cook University Hospital