Pancreatic Islet Cell Antibody
The first autoantibodies shown to be associated with insuli dependent diabetes mellitus (IDDM). They react with the whole islets not just insulin producing cells. Reportedly present in 90% of patients with IDDM at presentation, they are detected in a much lower proportion since the antibodies often disappear soon after (but sometimes before) diagnosis. There is an increased prevalence in relatives of patients with IDDM.
Diagnosis of type 1 diabetes.
Anti-islet cell antibodies are present in 90% of patients with Type I insulin-dependant/juvenile diabetes particularly around the time of diagnosis. They tend to disappear later unless there is multi-endocrine disorder. They are also found less commonly in non-diabetic relatives. They can serve as early markers to identify anti-islet cell autoimmunity before the onset of clinical symptoms.
Serum Separator Tube (SST)
Indirect immunfluorescence primate tissue
Assay range notes
Positive samples Titre 1:40-1:320
North of Cumbria