A test of limited value. Antibodies to cardiac muscle are found in the post-myocardial infarction (Dressler’s) syndrome, post-cardiotomy syndrome, post-pericardial trauma syndrome and in some cardiomyopathies. The antibodies disappear on recovery or with steroid therapy and recur with relapses. Their diagnostic value is low being also detected after cardiac surgery and after acute rheumatic fever. Antigens reported to be recognised by anti-cardiac antibodies include a 30kDa adenine nucleotide transporter protein, tropomyosin and myosin heavy chains and heat shock proteins.
Detection of Dressler’s syndrome – post myocardial infarction.
90% sensitivity for idiopathic dilated cardiomyopathy.
Serum Separator Tube (SST)
Indirect immunofluorescence primate tissue
Sheffield Protein Reference Unit