Paraneoplastic Antibodies (Anti-Hu,Yo, Ri, Ma)
|Alternative name:||Purkinje cell antibodies, Neuronal antibodies|
|Description:||A family of autoantibodies recognising antigens in the brain which are associated with a variety of neurological manifestations occurring as a result of malignancy, usually ovarian or small cell carcinoma of the lung. The autantibodies may also recognise the tumour. Patients present with paraneoplastic cerebellar degeneration usually triggering a search for a previously unsuspected malignancy.There are several groups of autantibodies:
See also anti-GAD antibodies and antibodies to voltage gated calcium or potassium channels.
This is a rapidly expanding field with new autoantibodies recognised annually. However, the diagnostic significance of many of the hew autoantibodies is poorly defined.
|Indication:||Paraneoplastic cerebellar syndrome & neuropathies associated with ovarian and small cell carcinoma of the lung.|
|Interpretation:||Hu antibodies associated with several neurological syndromes including subacute sensory neuropathy and encephelomyelits usually patients with small cell carcinoma. Ri antibodies associated with opsoclonus, ataxia, mystagmus and/or dysarthia usually patients with breast cancer. Yo antibodies associated with cerebellar symptoms; usually patients with ovarian cancer. An increasing number of paraneoplastic antibodies are being characterised.|
|Sample:||Serum Separator Tube (SST)|
|Assay details:||Indirect immunfluorescence rabbit cerebellum and other tissues|
|Restrictions:||Referred test: only available to Neurology staff.|
|Reference range:||Positive or negative|
|Assay range notes:|
|Turnaround time:||28 days|
|Analysing laboratory:||Churchill Hospital Department of Immunology|