Recommended sampling time -trough levels (consistently)
Valproate is used in the control of grand and petit mal epilepsy and as such requires therapeutic drug monitoring. The drug is completely absorbed reaching a peak in approximately 4 hours with 90% being protein bound. It affects and is affected by concomitant use of phenytoin. Although the mechanism is not fully understood it appears to increase gamma-aminobutyric acid (GABA) levels which have anticonvulsant properties.
Therapeutic Range: 50 – 100 mg/L
- Serum and Plasma (Lithium Heparin)
- Three patient identifiers from
- N.H.S. number
- Unit Number