|Background:||Creatinine clearance is used as an index of glomerular filtration rate (GFR). Although this produces an over estimate of the GFR due to a small amount of creatinine being excreted by the tubules, it has the advantage over other substances (e.g inulin) in that it is a natural metabolite.
Creatinine clearance decreases as renal function fails. It is used to monitor various renal diseases and allows the clinician to decide at what stage renal dialysis is essential.
Pharmacologically creatinine clearance is of help in managing the dosage of potentially toxic drugs which are cleared by the kidney.
The Radiography department occasionally requires creatinine clearance results urgently before administering cyto-toxic drugs.
|Reference Ranges:||Male: 85 – 125 µmol/min
Female: 75 – 115 µmol/min
|Specimen Requirements:||Sample type:
|Turnaround Time:||2 hours|