Also known as Orosomucoid. This is a “slow” acute phase protein. This protein used to be used in the diagnosis and monitoring of inflammatory bowel disease. AGP is an avid binder of basic drugs so changes in AGP cause significant changes in the pharmacokinetics of propanolol, imipramine, quinidine. CRP is a more useful indicator of acute phase.
Test is of limited value. Believed to be a marker of activity in inflammatory bowel disease – used in disease assessment of Crohn’s particularly in early stages of disease.
Raised levels associated with acute phase response. (inflammation, infection, tissue damage, malignancy) Reduced levels during pregnancy and in chronic liver disease.
Serum Separator Tube (SST)
Male: 0.6 – 1.2g/L
Female: 0.4 – 1.0g/L
Assay range notes
5-50yrs: 0.6-1.2g/l (male), 0.4-1.0g/l (female)
>50yrs: 0.8-2.0g/l (male/female)
Lower levels in children <1yr
5 – 7 days